Drug Delivery & Infusion

Develops stimulus responsive materials for biomedical use. Its lead product, Humidifeye, is a thermally responsive treatment for dry eye disease.

Makes the iLet automated insulin delivery system and the Mint patch pump, both of which dose insulin from continuous glucose monitor data.

Makes Bioactiv Matrix, a synthetic animal-free regenerative wound dressing produced by 3D printing. Approved by Singapore's HSA for end-use medical implants, with submissions pending in the US, EU, Australia and ASEAN.

Cambridge, Massachusetts spin-out from Mass General Brigham developing ReneuRx (Neural Ice), an injectable, drug-free thermal nerve block for musculoskeletal pain. FDA granted De Novo DEN250067 on August 21, 2026, creating product code SJA under 21 CFR 888.3048.

Makes patient-specific cranial implants and is developing NeuroPASS, a skull-embedded platform for brain access, sensing and drug delivery.

Makes Perio PODS, patient-matched single-use dental trays preloaded with a hydrogel that patients wear at home after scaling and root planing.

Makes the EpiFaith smart syringe, which signals the loss of resistance during epidural needle placement, and a version for central venous catheter insertion. The company says EpiFaith is in routine use at more than 30 US hospitals and pain centers.

HAI Solutions makes vascular access devices aimed at healthcare-associated infections, starting with a UVC device and cap that disinfect and protect needleless IV connectors.

Builds Pivot, a tubeless insulin patch pump that delivers basal and bolus insulin over a three-day wear period. Aimed at people with diabetes who have not adopted existing pumps.

Builds a wearable patch with DNA-based sensors on microneedles that continuously measures drug and biomarker levels. First product targets vancomycin therapeutic drug monitoring.

ETH Zurich spinout behind the COMS One Therapy System, a portable non-invasive device that uses concurrent optical and magnetic stimulation to treat non-healing wounds.

Develops injection platforms for high-viscosity biologics: PRIME, a needle-free jet injector, and PRIME Nexus, a reusable autoinjector. Neither is available for patient use yet.

Developing a smartphone integrated epinephrine auto-injector under an exclusive license from Thomas Jefferson University.

Sequel sells twiist, an automated insulin delivery pump that pairs with Abbott and Senseonics continuous glucose monitors and runs a dosing algorithm derived from Tidepool Loop.

Makes DripAssist, a low cost monitor and alarm that measures the rate of gravity fed IV fluid and blood transfusions without an infusion pump.

Makes pressure-enabled infusion catheters for liver and pancreatic embolization procedures in interventional radiology. Its cleared devices include the TriNav Infusion System, TriNav Infusion System LV, TriNav Advance and a pancreatic retrograde venous infusion system.

Makes VaporShield, a closed system transfer device for subcutaneous and intramuscular injection with a retractable needle and low dead space.