GI & Urology

Makes a stimulation device surgeons use to make the ureter and other smooth muscle structures move so they can be identified during surgery. Acquired by Northgate Technologies in April 2023.

Allurion makes a swallowable gastric balloon that needs no endoscopy or anesthesia and passes on its own after about four months. It pairs the balloon with a remote care app and scale.

Develops the ALPFA GRAIL System, a pulsed field ablation platform for benign prostatic hyperplasia. The device is investigational and in clinical study.

Developing Amber-UI, an adaptive neuromodulation implant that senses as well as stimulates, for mixed urinary incontinence in women. Spun out of Oxford University research.

Developing surgical robots that add AI guidance during procedures, starting with prostate surgery.

Radiofrequency vapor ablation delivered through an endoscope working channel. The system is cleared for GI tract ablation, and the company is testing a duodenal mucosal ablation procedure for type 2 diabetes under an FDA IDE.

Developing the Avvio Enhanced Lithotripsy System, which uses low-intensity ultrasound to activate injected microbubbles and break kidney stones without general anesthesia or routine stenting. Formerly Applaud Medical.

Sells devices for office-based gynecology, including the HERizon Vista hysteroscopy platform and the Symphion tissue removal system. It distributes Porter Instrument's Nitronox Plus nitrous oxide system to US gynecology practices.

Cornell Tech spinout running sequencing-based infectious disease tests from a CLIA lab in Long Island City. Its urine panel covers 44 urogenital pathogens and 16 resistance markers.

Makes Revi, an implantable tibial neuromodulation system for urgency urinary incontinence. FDA granted the De Novo in August 2023 and codified the device type as Class II in September 2026.

Makes the Butterfly Prostatic Retraction Device, an implant that mechanically retracts the lateral lobes of the prostate to restore urine flow without cutting or removing tissue. It is reversible and CE marked, and remains investigational in the US.

Runs the UroAmp platform, a urine-based tumor DNA test for non-muscle invasive bladder cancer, covering therapy response monitoring and post-treatment surveillance. Veracyte agreed to acquire the company in September 2026.

Develops ReCET, an endoscopic catheter that applies non-thermal pulsed electric fields to the duodenum to treat type 2 diabetes. Breakthrough-designated and in a randomized, sham-controlled IDE study.

EndoQuest is developing a flexible robotic system for endoluminal gastrointestinal surgery performed through natural orifices.

Makes a single-use gastroscope for upper endoscopy through the nose without general anesthesia or conscious sedation, in adults and children.

Builds the Vanquish water vapor ablation system, which delivers thermal energy to prostate tissue through the urethra. Founded by Michael Hoey and named for his father, who died of prostate cancer.

Develops blood tests that quantify liver function from cholate clearance to stage liver disease and guide varices screening. Runs its own CLIA laboratory in Colorado.

Builds software based therapeutics delivered through healthcare providers for gastrointestinal conditions such as irritable bowel syndrome.

Develops Holly, an implantable continuous dialysis system for end-stage kidney disease that filters blood through a surgically placed device rather than scheduled sessions.

Builds GI endoscopy devices around a shaft that stiffens on demand. Products are the Pathfinder rigidizing overtube and the Triton robotic colonoscopy system.

NeuroGyn develops PosStim, a pelvic neuromodulation platform aimed first at overactive bladder.

Makes EndoZip, an automated endoscopic suturing system for endoscopic sleeve gastroplasty. The device is run by a single physician and reduces stomach volume without incisions.

Developing PercStoma, a stent placed between bowel and skin through a single needle puncture under local anesthesia and X-ray guidance, as an alternative to surgical ostomy in malignant bowel obstruction.

ProVerum makes the ProVee System, a removable nitinol expander for the prostatic urethra that relieves BPH symptoms without cutting or heating tissue. It spun out of Trinity College Dublin.

Developing the Vasuki robotic system for upper and lower gastrointestinal endoscopy, with automation aimed at colonoscopy.

Developed the Connected Catheter, an indwelling catheter for men managing neurogenic bladder after spinal cord injury.

Builds the OpenFlo urinary catheter, which changes the tip and drainage configuration of a conventional Foley and is cleared for indwelling use up to 30 days.

Ventaris Surgical is developing a ureteroscopic system for kidney stone removal designed to achieve complete stone clearance in one procedure.

Developing the Zenflow Spring, an implant placed during an office based urology procedure to relieve urinary obstruction from benign prostatic hyperplasia.